Study finds metformin reduces COVID-19 viral load, viral rebound

A team of University of Minnesota researchers found that metformin, a drug commonly used to treat diabetes, can decrease the amount of COVID-19 virus in the body and lower the chances of the virus coming back strongly after initial treatment. The study was published in Clinical Infectious Diseases.

Study gauges effectiveness of COVID-19 burden mitigation policies

In a new study published in JAMA Network Open, researchers have created a dataset and data visualization dashboard to evaluate the effectiveness of state and territory-level policies enacted to reduce the severity of COVID-19's impact on older people served by home health care agencies and nursing homes.

The authors found many policies within states and territories did not correspond with reductions in community or nursing home-level COVID-19 burden (i.e. number of cases and mortality counts). This suggests that policy effectiveness may depend on implementation and compliance. The study also found that policies focused less on home health care agencies compared with nursing homes, despite both settings serving vulnerable older populations.

Data: Optimal initiation of Paxlovid in hospitalized COVID patients is 3 to 5 days Taking the SARS-CoV-2 antiviral drug nirmatrelvir-ritonavir (Paxlovid) 3 to 5 days after COVID-19 symptom onset—not earlier or later—may result in the greatest reduction in viral loads, viral transmission, and viral rebound in hospitalized patients, a University of Hong Kong–led study finds. CIDRAP

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